Title of article
Novel 2,2-dioxide-4,4-disubstituted-1,3-H-2,1,3-benzothiadiazines as non-nucleoside reverse transcriptase inhibitors
Author/Authors
Jeffrey W. Corbett، نويسنده , , Lisa A. Gearhart، نويسنده , , Soo S. Ko، نويسنده , , James D. Rodgers III، نويسنده , , Beverly C. Cordova، نويسنده , , Ronald M. Klabe، نويسنده , , Susan K. Erickson-Viitanen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
3
From page
193
To page
195
Abstract
Benzothiadiazine non-nucleoside reverse transcriptase inhibitors (NNRTIs) of HIV have been synthesized via a novel process to afford active inhibitors, with the most potent compound exhibiting an IC90=180 nM in a whole cell assay. The 2,2-dioxide-1H-2,1,3-benzothiadiazine ring system was constructed in one step from 2-amino-5-chlorobenzonitrile.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790601
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