Title of article
Synthesis and preliminary biological evaluation of [3H]-MRE 3008-F20: the first high affinity radioligand antagonist for the human A3 adenosine receptors
Author/Authors
Pier Giovanni Baraldi، نويسنده , , Barbara Cacciari، نويسنده , , Romeo Romagnoli، نويسنده , , Katia Varani، نويسنده , , Stefania Merighi، نويسنده , , Stefania Gessi، نويسنده , , Pier Andrea Borea، نويسنده , , Edward Leung، نويسنده , , Sarah L. Hickey، نويسنده , , Giampiero Spalluto، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
3
From page
209
To page
211
Abstract
The synthesis and the preliminary biological evaluation of the first high affinity radioligand antagonist for the human A3 adenosine receptor, named [3H]-MRE 3008-F20 are reported. [3H]-MRE 3008-20 bound human A3 receptors expressed in CHO cells with KD and Bmax value of 0.82±0.08 nM and 297±28 fmol/mg of protein, respectively. [3H]-MRE 3008-F20 represents a useful tool for a further characterization of A3 adenosine receptor subtype.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790605
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