Mechanistic studies on type I and type II dehydroquinase with (6R)- and (6S)-6-fluoro-3-dehydroquinic acids
Author/Authors :
Emily J. Parker، نويسنده , , Concepci?n Gonz?lez Bello، نويسنده , , John R. Coggins and Adrian J. Lapthorn، نويسنده , , Alastair R. Hawkins، نويسنده , , Chris Abell، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Pages :
4
From page :
231
To page :
234
Abstract :
(6R)- and (6S)-6-Fluoro-3-dehydroquinic acids are shown to be substrates for type I and type II dehydroquinases. Their differential reactivity provides insight into details of the reaction mechanism and enables a novel enzyme-substrate imine to be trapped on the type I enzyme.
