Author/Authors :
Michael B. Tollefson، نويسنده , , William F. Vernier، نويسنده , , Horng-Chih Huang، نويسنده , , Fang Ping Chen، نويسنده , , Emily J. Reinhard، نويسنده , , Judith Beaudry، نويسنده , , Bradley T. Keller، نويسنده , , David B. Reitz، نويسنده ,
Abstract :
A series of 2,3-disubstituted-4-phenylquinolines were prepared and were found to inhibit the apical sodium co-dependent bile acid transporter (ASBT). Alkyl and ester substitution at the 3-position showed comparable activities while substitution at the 2-position was much more sensitive to the nature of the substituent. The synthesis and in vitro potency data are presented for this novel class of compounds.
