Title of article
Design and biological evaluation of non-peptide analogues of omega-conotoxin MVIIA
Author/Authors
Stefan Menzler، نويسنده , , Jack A. Bikker، نويسنده , , Nirmala Suman-Chauhan، نويسنده , , David C. Horwell، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
3
From page
345
To page
347
Abstract
Omega-conotoxin MVIIA, a highly potent antagonist of the N-type voltage sensitive calcium channel, has shown utility in several models of pain and ischemia. We report a series of three alkylphenyl ether based analogues which mimic three key amino acids of the toxin. Two of the compounds have been found to exhibit IC50 values of 2.7 and 3.3 μM at the human N-type voltage sensitive calcium channel.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790638
Link To Document