(1,4-Benzothiazinyloxy)alkylpiperazine derivatives as potential antihypertensive agents

A series of compounds having a piperazine moiety variously linked to the benzothiazine nucleus were synthesized and evaluated for their in vitro α-adrenoceptor affinity by radioligand receptor binding assays. Some compounds bearing a oxyalkyl-(2-methoxyphenyl)piperazine side chain were good α1-adrenoreceptor ligands.