Author/Authors :
Geoffrey Wells، نويسنده , , Tracey D. Bradshaw، نويسنده , , Patrizia Diana، نويسنده , , Angela Seaton، نويسنده , , Dong-Fang Shi، نويسنده , , Andrew D. Westwell، نويسنده , , Malcolm F. G. Stevens، نويسنده ,
Abstract :
The synthesis of a series of new antitumour agents, the benzothiazole substituted quinol ethers and esters, is reported via the hypervalent iodine mediated oxidation of hydroxylated 2-phenylbenzothiazoles. The products were found to be active in vitro against human colon and breast cancer cell lines with IC50 values in the nanomolar range.
