Title of article :
Fluoresceinated FKBP12 ligands for a high-throughput fluorescence polarization assay
Author/Authors :
Gene M. Dubowchik، نويسنده , , Jonathan L. Ditta، نويسنده , , John J. Herbst، نويسنده , , Sagarika Bollini، نويسنده , , Alexander Vinitsky، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Abstract :
Several fluoresceinated FKBP12 ligands have been prepared for a high-throughput fluorescence polarization assay. Kis for FKBP12 rotamase inhibition by these ligands range from 1.3 μM to 32 nM, and their design is based on X-ray crystal structures of FKBP12 complexed with known immunophilin ligands.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
