Author/Authors :
Yongchul Kim، نويسنده , , Long-Xuan Zhao، نويسنده , , Tae-Hyung Kim، نويسنده , , Sun-mi Je، نويسنده , , Eunkyung Kim، نويسنده , , Heesung Choi، نويسنده , , Whi-Gun Chae، نويسنده , , Minsoo Park، نويسنده , , Jongwon Choi، نويسنده , , Yurngdong Jahng، نويسنده , , Eung Seok Lee، نويسنده ,
Abstract :
For the development of new anticonvulsive agents, γ-vinyl GABA (vigabatrin) and GABA mimetics derivatives were covalently coupled as potential dual acting prodrugs and evaluated for their anticonvulsive activities. Among the prepared compounds, 11 showed the most potent anticonvulsive activity, a shorter onset time and a broader spectrum compared to vigabatrin.
Scheme 1.
