Synthesis of a novel class of cdc25A inhibitors from vitamin D3

We have developed a novel class of cdc25A inhibitors by drastic modification of the hydrophobic and hydrophilic substructures of dysidiolide. The unsaturated derivative Figure 1 and Scheme 1 strongly inhibited cdc25A (IC50=7.7 μM) and caused G1 arrest of HL60 cells. Figure 1. Scheme 1.