Author/Authors :
Shigeki Hibi، نويسنده , , Katsuya Tagami، نويسنده , , Kouichi Kikuchi، نويسنده , , Hiroyuki Yoshimura، نويسنده , , Kenji Tai، نويسنده , , Takayuki Hida، نويسنده , , Naoki Tokuhara، نويسنده , , Toshihiko Yamauchi، نويسنده , , Mitsuo Nagai، نويسنده ,
Abstract :
Synthesis and structure–activity relationships (SAR) of RARα-selective agonists are discussed. 4-[5-(5,8-Dimethyl-2H-3-chromenyl)-1H-2-pyrrolyl]benzoic acid (12a), which possesses a flat structural moiety and an oxygen atom at the hydrophobic part, showed highly selective transactivation activity at the RARα receptor.
