Title of article
Yohimbine dimers exhibiting binding selectivities for human α2a- versus α2b-adrenergic receptors
Author/Authors
Weiping Zheng، نويسنده , , Longping Lei، نويسنده , , Shilpa Lalchandani، نويسنده , , Guoping Sun، نويسنده , , Dennis R. Feller، نويسنده , , Duane D. Miller، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
627
To page
630
Abstract
A series of yohimbine dimers was prepared and evaluated at the human α2a- and α2b-adrenergic receptors (ARs) expressed in Chinese hamster ovary (CHO) cells. All dimers display higher binding selectivities for α2a versus α2b subtype than yohimbine, and four compounds (3d, 3e, 3g and 3i) represent the most potent and α2a- versus α2b-AR selective ligands identified so far.
Scheme 1.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790701
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