Title of article
Isoxazolines and isoxazoles as factor Xa inhibitors
Author/Authors
James R. Pruitt، نويسنده , , Donald J. Pinto، نويسنده , , Melissa J. Estrella، نويسنده , , Lori L. Bostrom، نويسنده , , Robert M. Knabb، نويسنده , , Pancras C. Wong، نويسنده , , Matthew R. Wright، نويسنده , , Ruth R. Wexler، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
5
From page
685
To page
689
Abstract
3,4,5-Trisubstituted isoxazolines (2) and isoxazoles ( 3) were prepared and evaluated for their in vitro and in vivo antithrombotic efficacy. They were compared to 3,5,5-trisubstituted isoxazolines (1) for Factor Xa selectivity and potency. They were also compared in an arterio-venous (A-V) shunt model of thrombosis.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790715
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