Author/Authors :
James R. Pruitt، نويسنده , , Donald J. Pinto، نويسنده , , Melissa J. Estrella، نويسنده , , Lori L. Bostrom، نويسنده , , Robert M. Knabb، نويسنده , , Pancras C. Wong، نويسنده , , Matthew R. Wright، نويسنده , , Ruth R. Wexler، نويسنده ,
Abstract :
3,4,5-Trisubstituted isoxazolines (2) and isoxazoles ( 3) were prepared and evaluated for their in vitro and in vivo antithrombotic efficacy. They were compared to 3,5,5-trisubstituted isoxazolines (1) for Factor Xa selectivity and potency. They were also compared in an arterio-venous (A-V) shunt model of thrombosis.
