Title of article
The synthesis and vasopressin (AVP) antagonist activity of a novel series of n-aroyl-2,4,5,6-tetrahydropyrazolo [3,4-d]thieno[3,2-b]azepines
Author/Authors
J. Donald Albright، نويسنده , , Efren G. Delos Santos، نويسنده , , John P. Dusza، نويسنده , , Peter S. Chan، نويسنده , , Joseph Coupet، نويسنده , , Xun Ru، نويسنده , , H. Mazandarani، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
695
To page
698
Abstract
Synthesis and SAR of N-[4-[(4,5-dihydropyrazolo[3,4-d]thieno[3,2-b]azepin-6(2H)-yl)carbonyl]phenyl]benzamides as arginine vasopressin (AVP) receptor antagonists are discussed. Potent orally active AVP receptor antagonists are produced when the benzamide moiety contains a phenyl group at the 2-position. Similar analogues of 4,6,7,8-tetrahydro-5H-thieno[3,2-b]azepine and VPA-985 are reported
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790717
Link To Document