Title of article
Synthesis and biological activity of fluoro-substituted pyrrolo[2,3-d]pyrimidines: The development of potential positron emission tomography imaging agents for the corticotropin-releasing hormone type 1 receptor
Author/Authors
Ling-Wei Hsin، نويسنده , , Elizabeth L. Webster، نويسنده , , George P. Chrousos، نويسنده , , Philip W. Gold، نويسنده , , William C. Eckelman، نويسنده , , Carlo Contoreggi، نويسنده , , Kenner C. Rice، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
707
To page
710
Abstract
A series of fluoro-substituted 4-(dialkylamino)pyrrolo[2,3-d]pyrimidines was synthesized and their binding affinity for corticotropin-releasing hormone type 1 receptor (CRHR1) was investigated. Compounds 11a and 11b possessed very high CRHR1 affinity (Ki=3.5, 0.91 nM, respectively). They are promising candidates for the development of 18F-containing nonpeptide PET radioligands for CRHR1.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790720
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