Author/Authors :
Jeroen C. Verheijen، نويسنده , , Anne-Marie M. van Roon، نويسنده , , Nico J. Meeuwenoord، نويسنده , , Hanneke R. Stuivenberg، نويسنده , , Suzanne F. Bayly، نويسنده , , Ling Chen، نويسنده , , Gijsbert A. van der Marel، نويسنده , , Paul F. Torrence، نويسنده , , Jacques H. van Boom، نويسنده ,
Abstract :
Incorporation of a 4-hydroxy-N-acetylprolinol nucleotide analogue at the 3′-terminus of DNA or 2-5A-DNA sequences resulted in a significantly enhanced 3′-exonuclease resistance while the affinity for complementary RNA was only slightly decreased. Furthermore, the binding to and activation of human RNase L by thus modified 2-5A-DNA conjugates was not altered as compared to the parent unmodified 2-5A-DNAs.
