Title of article :
Pyrrolo[3,2,1-ij]quinoline derivatives, a 5-HT2c receptor agonist with selectivity over the 5-HT2a receptor: potential therapeutic applications for epilepsy and obesity
Author/Authors :
Methvin Isaac، نويسنده , , Abdelmalik Slassi*، نويسنده , , Anne OʹBrien، نويسنده , , Louise Edwards، نويسنده , , Neil MacLean، نويسنده , , Donna Bueschkens، نويسنده , , David K. H. Lee، نويسنده , , Kirk McCallum، نويسنده , , Ines De Lannoy، نويسنده , , Lidia Demchyshyn، نويسنده , , Rajender Kamboj، نويسنده ,
Abstract :
A series of pyrrolo[3,2,1-ij]quinoline derivatives was synthesized, evaluated for their activity against the 5-HT2c and 5-HT2a, receptors and found to be agonists at 5-HT2c with selectivity over 5-HT2a.
