Title of article
Inhibition of neuraminidase with neuraminic acid C-glycosides
Author/Authors
Qun Wang، نويسنده , , Michael Wolff، نويسنده , , Tülay Polat، نويسنده , , Yuguo Du، نويسنده , , Robert J. Linhardt and Barbara A. Seaton، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
941
To page
944
Abstract
Neuraminic (sialic) acid based α-C-glycosides have been synthesized and their inhibitory activity towards bacterial neuraminidase (sialidase) was examined. While some C-glycosides were found to be potent inhibitors (Ki 15–30 μM) of this neuraminidase, others afforded no measurable activity. The structure–activity relationship of these C-glycosides is discussed in the context of other previously reported sialidase inhibitors.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790769
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