Author/Authors :
Fatih M. Uckun، نويسنده , , Chen Mao، نويسنده , , Alexei O. Vassilev، نويسنده , , Christopher S. Navara، نويسنده , , Rama Krishna S. Narla، نويسنده , , Shyi-Tai Jan، نويسنده ,
Abstract :
A novel mono-THF containing synthetic anticancer drug (WHI-261) was designed for targeting a previously unrecognized unique narrow binding cavity on the surface of tubulin. The anti-cancer activity of WHI-261 was confirmed using MTT assays. The structure-based design, synthesis, and biological activity of WHI-261 are reported.
