Author/Authors :
Yong Gong، نويسنده , , Michael Becker، نويسنده , , Yong Mi Choi-Sledeski، نويسنده , , Roderick S. Davis، نويسنده , , Joseph M. Salvino، نويسنده , , Valeria Chu، نويسنده , , Karen D. Brown، نويسنده , , Henry W. Pauls، نويسنده ,
Abstract :
A focused library (4×14) prepared from 4-aminopyridine and 4-, 5-, and 6-azoindole templates was synthesized using 14 polymer supported 4-amido-2,3,5,6-tetrafluorophenyl (TFP) sulfonate esters inputs. Several compounds were identified as factor Xa inhibitors (IC50≤0.1 μM) helping to establish the SAR among these four series of azarene pyrrolidinones.
