Author/Authors :
Krishna K. Murthi، نويسنده , , Marja Dubay، نويسنده , , Christopher McClure، نويسنده , , Leonardo Brizuela، نويسنده , , Michael D. Boisclair، نويسنده , , Peter J. Worland، نويسنده , , Muzammil M. Mansuri، نويسنده , , Kollol Pal، نويسنده ,
Abstract :
Cyclin dependent kinases (CDKs) along with the complementary cyclins form key regulatory checkpoint controls on the cell cycle. Flavopiridol is a synthetic flavone that shows potent and selective cyclin-dependent kinase inhibitory activity. In this paper, we report modifications of the 3-hydroxy-1-methylpiperidinyl (D ring) of flavopiridol and their effect on CDK inhibitory activity.
