Title of article :
Novel α-glucosidase inhibitors with a tetrachlorophthalimide skeleton
Author/Authors :
Sonei Sou، نويسنده , , Satoshi Mayumi، نويسنده , , Hiroyasu Takahashi، نويسنده , , Ryu Yamasaki، نويسنده , , Shizuo Kadoya، نويسنده , , Mikiko Sodeoka، نويسنده , , Yuichi Hashimoto، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Abstract :
Novel α-glucosidase inhibitors with a tetrachlorophthalimide skeleton were prepared and their structure–activity relationships were analyzed. Among them, N-phenyl-4,5,6,7-tetrachlorophthalimide (CP0P: 2) and N-(4-phenylbutyl)-4,5,6,7-tetrachlorophthalimide (CP4P: 6) showed very potent inhibitory activity, being more potent than 1-deoxynojirimycin (dNM: 1). Mechanistic studies revealed that CP0P (2) and CP4P (6) inhibit α-glucosidase non-competitively and competitively, respectively.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
