Title of article
Novel α-glucosidase inhibitors with a tetrachlorophthalimide skeleton
Author/Authors
Sonei Sou، نويسنده , , Satoshi Mayumi، نويسنده , , Hiroyasu Takahashi، نويسنده , , Ryu Yamasaki، نويسنده , , Shizuo Kadoya، نويسنده , , Mikiko Sodeoka، نويسنده , , Yuichi Hashimoto، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
1081
To page
1084
Abstract
Novel α-glucosidase inhibitors with a tetrachlorophthalimide skeleton were prepared and their structure–activity relationships were analyzed. Among them, N-phenyl-4,5,6,7-tetrachlorophthalimide (CP0P: 2) and N-(4-phenylbutyl)-4,5,6,7-tetrachlorophthalimide (CP4P: 6) showed very potent inhibitory activity, being more potent than 1-deoxynojirimycin (dNM: 1). Mechanistic studies revealed that CP0P (2) and CP4P (6) inhibit α-glucosidase non-competitively and competitively, respectively.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790804
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