Title of article
Phosphonamidate and phosphothioate dipeptides as potential inhibitors of VanX
Author/Authors
Ke-Wu Yang، نويسنده , , Jeffrey J. Brandt، نويسنده , , Lisa L. Chatwood، نويسنده , , Michael W. Crowder، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
3
From page
1085
To page
1087
Abstract
In an effort to prepare novel inhibitors of VanX, N-[(1-aminoethyl)hydroxyphosphinyl]- -alanine 1 and S-[(aminoethyl)hydroxyphosphinyl]-thiolacetic acid 2 were synthesized and evaluated as inhibitors of VanX. Phosphonamidate 1 was shown to be a partial competitive inhibitor of VanX with a Ki of 36±3 μM, and phosphothioate 2 was shown not to inhibit VanX.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790805
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