Author/Authors :
Mar?a L. L?pez-Rodr?guez، نويسنده , , Esther Porras، نويسنده , , Bellinda Benhamu، نويسنده , , José. A. Ramos، نويسنده , , M. José Morcillo، نويسنده , , José L. Lavandera، نويسنده ,
Abstract :
In order to make the first contribution to the elucidation of essential structural features for 5-HT7 antagonism, a set of thirty 5-HT7 antagonists were selected from the literature. A pharmacophore model was built using Molecular Modeling studies with Catalyst program. The information contained in this model was validated with new synthesized compounds.
