Title of article :
Phosphate prodrugs of PD154075
Author/Authors :
Zhijian Zhu، نويسنده , , Huai-Gu Chen، نويسنده , , Om P. Goel، نويسنده , , O. Helen Chan، نويسنده , , Linda A. Stilgenbauer، نويسنده , , Barbra H. Stewart، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Abstract :
In the preparation of phosphate prodrugs of PD154075, several strategies of linking a phosphate group to the indole moiety were studied. A novel linker, p-hydroxymethylbenzoyloxymethoxycarbonyl, was discovered to provide the phosphate prodrug of PD154075 (compound 9) with significantly increased aqueous solubility, sufficient stability in aqueous solution and good bio-reconversion in vivo.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
