Cyclic thioether peptide mimetics as VCAM–VLA-4 antagonists
Author/Authors :
Nader Fotouhi، نويسنده , , Pramod Joshi، نويسنده , , Jefferson W. Tilley، نويسنده , , Karen Rowan، نويسنده , , Virginia Schwinge، نويسنده , , Barry Wolitzky، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Pages :
3
From page :
1167
To page :
1169
Abstract :
Selective substitution of a sulfur atom by carbon in a highly potent 13-membered cyclic disulfide was accomplished by intramolecular displacement of a bromide. The potency of the resulting thioethers in the VCAM/VLA-4 assay was dependant on ring size and the position of the sulfur atom.
