Author/Authors :
Takashi Owa، نويسنده , , Tatsuo Okauchi، نويسنده , , Kentaro Yoshimatsu، نويسنده , , Naoko Hata Sugi، نويسنده , , Yoichi Ozawa، نويسنده , , Takeshi Nagasu، نويسنده , , Nozomu Koyanagi، نويسنده , , Tadashi Okabe، نويسنده , , Kyosuke Kitoh، نويسنده , , Hiroshi Yoshino، نويسنده ,
Abstract :
A series of compounds containing an N-(7-indolyl)benzenesulfonamide pharmacophore was synthesized and evaluated as a potential antitumor agent. Cell cycle analysis with P388 murine leukemia cells revealed that there were two different classes of potent cell cycle inhibitors; one disrupted mitosis and the other caused G1 accumulation. Herein described is the SAR summary of the substituent patterns on this pharmacophore template.
