Author/Authors :
Fabrizio Gasparini، نويسنده , , Werner Inderbitzin، نويسنده , , Eric Francotte، نويسنده , , Gabrielle Lecis، نويسنده , , Paul Richert، نويسنده , , Zorica Dragic، نويسنده , , Rainer Kuhn، نويسنده , , Peter J. Flor، نويسنده ,
Abstract :
A new synthesis of (R,S)-PPG (4-phosphonophenylglycine) and the separation of the protected enantiomers leading after deprotection to (+)- and (−)-PPG are described. Pharmacological characterization at the group III metabotropic glutamate receptors hmGluR4a and hmGluR7b revealed (+)-PPG as the active enantiomer.
