Title of article
(+)-4-Phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist
Author/Authors
Fabrizio Gasparini، نويسنده , , Werner Inderbitzin، نويسنده , , Eric Francotte، نويسنده , , Gabrielle Lecis، نويسنده , , Paul Richert، نويسنده , , Zorica Dragic، نويسنده , , Rainer Kuhn، نويسنده , , Peter J. Flor، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
1241
To page
1244
Abstract
A new synthesis of (R,S)-PPG (4-phosphonophenylglycine) and the separation of the protected enantiomers leading after deprotection to (+)- and (−)-PPG are described. Pharmacological characterization at the group III metabotropic glutamate receptors hmGluR4a and hmGluR7b revealed (+)-PPG as the active enantiomer.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790842
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