Title of article
The synthesis and in vitro cytotoxic studies of novel oxa-spermidine derivatives and homologues
Author/Authors
Vladimir A. Kuksa، نويسنده , , Valentin A. Pavlov، نويسنده , , Paul Kong Thoo Lin، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
3
From page
1265
To page
1267
Abstract
A series of oxa-spermidine derivatives and homologues were prepared and their anticancer properties were evaluated. All these compounds showed an average GI50 value in the range of 3.9–28.9 μM. SAR studies showed that the presence of a sulphonamido functionality and the length of the alkyl chain are important factors for an enhanced activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790848
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