Author/Authors :
Gian Mario Cingolani، نويسنده , , Antonio Di Stefano، نويسنده , , Barbara Mosciatti، نويسنده , , Fabrizio Napolitani، نويسنده , , Gianfabio Giorgioni، نويسنده , , Massimo Ricciutelli، نويسنده , , Francesco Claudi، نويسنده ,
Abstract :
The synthesis and in vitro chemical and enzymatic stability of -(+)-3-(3-hydroxy-4-pivaloyloxybenzyl)-2,5-diketomorpholine (9) as -Dopa prodrug are described. Prodrug 9 possesses a good lipophilicity (log P=2.153 ± 0.017), is stable in aqueous buffer solutions (pH 1.3 and 7.4), and in 80% rat and human plasma it is turned into -Dopa.
