Author/Authors :
Kye Jung Shin، نويسنده , , Ki Dong Koo، نويسنده , , Kyung Ho Yoo، نويسنده , , Dong Chan Kim، نويسنده , , Dong Jin Kim، نويسنده , , Sang Woo Park، نويسنده ,
Abstract :
The synthesis and biological activities of a series of new 1β-methylcarbapenems 1a–l having tetrazolothioether moiety at C-5 position of pyrrolidine were described. Among these compounds, 1c showed the most potent antibacterial activity and advanced pharmacokinetics compared with imipenem and meropenem.
