Author/Authors :
Sin Chul Moon، نويسنده , , Jung-Hyu Shin، نويسنده , , Bong Ho Jeong، نويسنده , , Hee Seok Kim، نويسنده , , Byung Soo Yu، نويسنده , , Ji Sook Lee، نويسنده , , Bang Sook Lee، نويسنده , , Sung Keon Namgoong، نويسنده ,
Abstract :
New tetrakis(multifluoro-4-pyridyl)porphin derivatives (2–4) and water soluble porphyrin (5) were synthesized to investigate their interactions with acetylcholinesterase from electric eel. These compounds have been found to be the potent reversible inhibitors of the enzyme with Ki values of μM range. In addition, porphyrin (5) showed broad spectrum of anticancer activities.
