Author/Authors :
Kikoh Obi، نويسنده , , Jun-ichiro Uda، نويسنده , , Kazuhiko Iwase، نويسنده , , Osamu Sugimoto، نويسنده , , Hiroyuki Ebisu، نويسنده , , Akira Matsuda and Fuyuhiko Inagaki، نويسنده ,
Abstract :
A series of novel nikkomycin analogue inhibitors of the chitin synthase of fungal cell wall was synthesized and evaluated for their inhibitory activities. Among them, the compound having a phenanthrene group at the terminal amino acid was found to possess strong anti-chitin synthase activity.
