Title of article
Design, synthesis, and biological evaluation of fluoronitrophenyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase
Author/Authors
Dale L. Boger، نويسنده , , Thomas H. Marsilje، نويسنده , , René A. Castro، نويسنده , , Michael P. Hedrick، نويسنده , , Qing-jin، Meng نويسنده , , Stephen J. Baker، نويسنده , , Jae Hoon Shim، نويسنده , , Stephen J. Benkovic، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
5
From page
1471
To page
1475
Abstract
The examination results of a novel series of potential inhibitors of glycinamide ribonucleotide transformylase (GAR Tfase) and aminoimidazole carboxamide transformylase (AICAR Tfase) are reported. These agents incorporate an electrophilic fluoronitrophenyl group that can potentially react with an active site nucleophile or the substrate GAR/AICAR amine via nucleophilic aromatic substitution.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790899
Link To Document