Title of article
Selective α1a adrenergic receptor antagonists based on 4-aryl-3,4-dihydropyridine-2-ones
Author/Authors
Philippe G. Nantermet، نويسنده , , James C. Barrow، نويسنده , , Harold G. Selnick، نويسنده , , Carl F. Homnick، نويسنده , , Roger M. Freidinger، نويسنده , , Raymond S. L. Chang، نويسنده , , Stacey S. OʹMalley، نويسنده , , Duane R. Reiss، نويسنده , , Theodore P. Broten، نويسنده , , Richard W. Ransom، نويسنده , , Douglas J. Pettibone، نويسنده , , Timothy Olah، نويسنده , , Carlos Forray، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
1625
To page
1628
Abstract
A series of α1a receptor antagonists derived from a 4-aryl-3,4-dihydropyridine-2-one heterocycle is disclosed. Potency in the low nanomolar to picomolar range along with high selectivity was obtained. In vivo efficacy in a prostate contraction model in rats was observed with a few derivatives.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790937
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