Author/Authors :
Takahide Nishi، نويسنده , , Koki Ishibashi، نويسنده , , Toshiyasu Takemoto، نويسنده , , Katsuyoshi Nakajima، نويسنده , , Tetsuya Fukazawa، نويسنده , , Yukiko Iio، نويسنده , , Kazuhiro Itoh، نويسنده , , Osamu Mukaiyama، نويسنده , , Takeshi Yamaguchi، نويسنده ,
Abstract :
We report herein the synthesis and stereochemical structure–activity relationships of novel morpholine analogues 12 and 13 with regards to NK1, NK2 and NK3 tachykinin receptor binding affinity. An essential requirement for more potent binding affinities was controlled by absolute configuration. (S,R)-12 and (S,R)-13 exhibited high binding affinities for NK1, NK2 and NK3 receptors.
