• Title of article

    Synthesis and biological property of carba and 20-Deoxo analogues of arenastatin A

  • Author/Authors

    Nobutoshi Murakami، نويسنده , , Weiqi Wang، نويسنده , , Satoru Tamura، نويسنده , , Motomasa Kobayashi، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2000
  • Pages
    4
  • From page
    1823
  • To page
    1826
  • Abstract
    The carba analogue, in which a methylene group is substituted for the oxygen atom linked to C-15, and 20-deoxo analogue of arenastatin A, a potent cytotoxic spongean depsipeptide, were synthesized. Both analogues lacking the 15,20-ester function, which was easily metabolized in serum, showed good stability in serum as well as moderate cytotoxic activity against KB cells and better solubility.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2000
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    790985

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=790985