Title of article
Synthesis and erythropoietin receptor binding affinities of N,N-disubstituted amino acids
Author/Authors
Peter J. Connolly، نويسنده , , Steven K. Wetter، نويسنده , , William V. Murray، نويسنده , , Dana L. Johnson، نويسنده , , Frank J. McMahon، نويسنده , , Francis X. Farrell، نويسنده , , Jennifer Tullai، نويسنده , , Linda K. Jolliffe، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
5
From page
1995
To page
1999
Abstract
N,N-Dicinnamyl, N-benzyl-N-cinnamyl, and N,N-dibenzyl amino acids were prepared and evaluated in an EPO binding assay. Several derivatives of aspartic acid, glutamic acid, and lysine exhibited moderate (10–50 μM) affinity for EBP; ‘dimerization’ of the most potent analogues by coupling with linear diamines led to EPO competitors having 1–2 μM binding affinities.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791024
Link To Document