Author/Authors :
Peter J. Connolly، نويسنده , , Steven K. Wetter، نويسنده , , William V. Murray، نويسنده , , Dana L. Johnson، نويسنده , , Frank J. McMahon، نويسنده , , Francis X. Farrell، نويسنده , , Jennifer Tullai، نويسنده , , Linda K. Jolliffe، نويسنده ,
Abstract :
N,N-Dicinnamyl, N-benzyl-N-cinnamyl, and N,N-dibenzyl amino acids were prepared and evaluated in an EPO binding assay. Several derivatives of aspartic acid, glutamic acid, and lysine exhibited moderate (10–50 μM) affinity for EBP; ‘dimerization’ of the most potent analogues by coupling with linear diamines led to EPO competitors having 1–2 μM binding affinities.
