Title of article :
use of proline bioisosteres in potential HIV protease inhibitors: phenylalanine-2-thiophenoxy-3-pyrrolidinone: synthesis and anti-HIV evaluation
Author/Authors :
J. L. Kraus، نويسنده , , M. Bouygues، نويسنده , , J. Courcambeck، نويسنده , , J. C. Chermann، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Abstract :
The synthesis of new phenylalanine-2-thiophenoxy-3-pyrrolidinones is described. Anti-HIV recombinant protease assays and HIV infected cell culture assays (observation of syncytia) demonstrated the potent anti-HIV activity of this new class of pseudopeptides.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
