Author/Authors :
Vittorio Caprio، نويسنده , , Berengere Guyen، نويسنده , , Yaw Opoku-Boahen، نويسنده , , John Mann، نويسنده , , Sharon M. Gowan، نويسنده , , Lloyd M. Kelland، نويسنده , , Martin A. Read، نويسنده , , Stephen Neidle، نويسنده ,
Abstract :
The bis-dimethylaminoethyl derivative of quindoline (10H-indolo[3,2-b]quinoline), an alkaloid from the West African shrub Cryptolepis sanguinolenta, has been synthesised. This has been shown to have modest cytotoxicity, as well as inhibitory activity against the telomerase enzyme. It is hypothesised that the latter activity is due to stabilisation of an intermediate guanine-quadruplex complex, in accordance with computer modelling.
