Author/Authors :
Shu-Hui Chen، نويسنده , , Xicheng Sun، نويسنده , , Robert Boyer، نويسنده , , Jonathan Paschal، نويسنده , , Doug Zeckner، نويسنده , , William Current، نويسنده , , Mark Zweifel، نويسنده , , Michael Rodriguez، نويسنده ,
Abstract :
A series of aliphatic side-chain analogues of pseudomycin was synthesized and evaluated during the course of our side-chain SAR effort. We found that several of the pseudomycin side-chain analogues (e.g., 10) exhibited good in vitro activity against all three major fungi responsible for systemic fungal infections.
