Title of article
Design, synthesis, and discovery of 3-piperazinyl-3,4-dihydro-2(1H)-quinolinone derivatives: a novel series of mixed dopamine D2/D4 receptor antagonists
Author/Authors
He Zhao، نويسنده , , Andrew Thurkauf، نويسنده , , Julia Braun، نويسنده , , Robin Brodbeck، نويسنده , , Andrzej Kieltyka، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
2119
To page
2122
Abstract
3-Piperazinyl-3,4-dihydro-2(1H)-quinolinone derivatives (δ-lactams) were designed, synthesized, and identified as a new series of mixed dopamine D2/D4 receptor antagonists. To further the structure–activity relationship (SAR) study, 3-piperazinyl-indolin-2-ones (γ-lactams) and 3-piperazinyl-3H,4H,5H-benzo[f]azepin-2-ones ( -lactams) were also prepared and examined.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791053
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