Author/Authors :
Gitendra C. Paul، نويسنده , , Erik De Clercq، نويسنده , , Christophe Pannecouque، نويسنده , , Myriam Witvrouw، نويسنده , , Tracy L. Loftus، نويسنده , , Jim A. Turpin، نويسنده , , Robert W. BuckheitJr.، نويسنده , , Mark Cushman، نويسنده ,
Abstract :
The binding of the anti-HIV agent cosalane to CD4 is thought to involve ionic interactions of negatively charged carboxylates of the ligand with positively charged residues on the surface of the protein. An investigation of the optimal anion distances for anti-HIV activity in a series of cosalane tetracarboxylate analogues has been completed, and maximal activity results when the two proximal and the two distal carboxylates are separated by eight atoms.
