Author/Authors :
Eugene B. Grant، نويسنده , , Deodialsingh Guiadeen، نويسنده , , Ellen Z. Baum، نويسنده , , Barbara D. Foleno، نويسنده , , Haiyong Jin، نويسنده , , Deborah A. Montenegro، نويسنده , , Erin A. Nelson، نويسنده , , Karen Bush and Osnat Herzberg، نويسنده , , Dennis J. Hlasta، نويسنده ,
Abstract :
β-Lactam antibiotics such as the cephalosporins and penicillins have diminished clinical effectiveness due to the hydrolytic activity of diverse β-lactamases, especially those in molecular classes A and C. A structure–activity relationship (SAR) study of a high-throughput screening lead resulted in the discovery of a potent and selective non-β-lactam inhibitor of class C β-lactamases.
