Author/Authors :
Thomas E. Goodwin، نويسنده , , Carole J. Boylan، نويسنده , , William L. Current، نويسنده , , John C. Byrd، نويسنده , , Clint B. Edwards، نويسنده , , Danny A. Fuller، نويسنده , , Jennifer L. Green، نويسنده , , Christine D. Larocca، نويسنده , , Kevin D. Raney، نويسنده , , Ashley S. Ross، نويسنده , , W. Andrew Tucker، نويسنده ,
Abstract :
New analogues of the venerable antimalarial drug primaquine have been synthesized and bioassayed in vivo against Pneumocystis carinii, a life-threatening infection common among immunosuppressed patients. Two of these new compounds are significantly more active than primaquine itself, and provide new information for future drug design and development in this area.
