Author/Authors :
William Billard، نويسنده , , Herbert BinchIII، نويسنده , , Kristen Bratzler، نويسنده , , Lian-Yong Chen، نويسنده , , Gordon CrosbyJr.، نويسنده , , Ruth A. Duffy، نويسنده , , Sundeep Dugar، نويسنده , , Jean Lachowicz، نويسنده , , Robert McQuade، نويسنده , , Pradeep Pushpavanam، نويسنده , , Vilma B. Ruperto، نويسنده , , Lisa A. Taylor، نويسنده , , John W. Clader، نويسنده ,
Abstract :
Piperidine analogues of our previously described piperazine muscarinic antagonists are described. Piperidine analogues show a distinct structure–activity relationship (SAR) that differs from comparable piperazines. Compounds with high selectivity and improved potency for the M2 receptor have been identified. The lead compound, 12b, increases acetylcholine release in vivo. Compounds of this class may be useful for the treatment of cognitive disorders such as Alzheimerʹs disease (AD).
