Author/Authors :
Makoto Koizumi، نويسنده , , Keika Akahori، نويسنده , , Toshinori Ohmine، نويسنده , , Shinya Tsutsumi، نويسنده , , Junko Sone، نويسنده , , Toshiyuki Kosaka، نويسنده , , Masakatsu Kaneko، نويسنده , , Satoshi Kimura، نويسنده , , Kaoru Shimada، نويسنده ,
Abstract :
2′-Deoxyguanosine residues of a 3′,5′-end-modified hexadeoxyribonucleotide (R-95288) with anti-HIV-1 activity were substituted with N2-methyl-2′-deoxyguanosine (m2dG). These modified oligodeoxyribonucleotides (ODNs) showed a 2-fold higher activity than R-95288. Also, the CD spectra of these ODNs indicated that the m2dG modification stabilized the tertiary structure of the G-quadruplex.
