Author/Authors :
Yoshio Okada، نويسنده , , Yuko Tsuda، نويسنده , , Keiko Wanaka، نويسنده , , Mayako Tada، نويسنده , , Utako Okamoto، نويسنده , , Shosuke Okamoto، نويسنده , , Akiko Hijikata-Okunomiya، نويسنده , , Gyorgyi Bokonyi، نويسنده , , Béla Szende، نويسنده , , Gyorgy Keri، نويسنده ,
Abstract :
trans-4-Aminomethylcyclohexanecarbonyl-Tyr(O-Pic)-octylamide (YO-2) inhibited plasmin (PL) selectively, while trans-4-aminomethylcyclohexanecarbonyl-Phe-4-carboxymethylanilide (YO-1) inhibited plasma kallikrein (PK). YO-2 induced apoptosis of M1 (melanoma) cell line and HT29 colon carcinoma cells during 24 h through activation of caspase-3, while YO-1 did not affect either cell line even during 48 h.
