Author/Authors :
Mauro Napoletano، نويسنده , , Gabriele Norcini، نويسنده , , Franco Pellacini، نويسنده , , Francesco Marchini، نويسنده , , Gabriele Morazzoni، نويسنده , , Pierpaolo Ferlenga، نويسنده , , Lorenzo Pradella، نويسنده ,
Abstract :
This communication describes the synthesis and in vitro evaluation of a novel and potent series of phosphodiesterase type IV (PDE4) inhibitors. The compounds described represent conformationally constrained analogues of RP 73401, Piclamilast. Preliminary evidences of reduced side effects of 11 compared to standards are also reported.
