Title of article
Synthesis and preliminary analysis of a P-glycoprotein-specific [3H]-benzophenone photoaffinity label based on (−)-stipiamide
Author/Authors
Merritt B. Andrus، نويسنده , , Timothy M. Turner، نويسنده , , Zuben E. Sauna، نويسنده , , Suresh V. Ambudkar، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
2275
To page
2278
Abstract
A benzophenone photoaffinity label 9 based on the polyene natural product (−)-stipiamide has been constructed using a diaminoethane spacer and the radioactive agent [3H]-BZDC (N-succinimidyl p-benzoyl-(2,3-3H)-dehydrocinnamate). Photoaffinity experiments show specific binding to human P-glycoprotein (Pgp) in the presence of cis-flupentixol but not with cyclosporin A.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791089
Link To Document